This is the warning label from the Azilect website:
http://www.azilect.com/ImportantSafe...a-f8a7cea5d359
Elevated blood pressure is possible, if you have a drug interaction or are eating tyramine foods.
While the conclusion of this study says the dietary restrictions are not necessary, 3 subjects did get blood pressure elevations with tyramine and levodopa.
http://www.ncbi.nlm.nih.gov/pubmed/1...m&ordinalpos=4
This drug interacts with many drugs.
This is another paper, suggesting the dietary rules still be followed:
http://www.ncbi.nlm.nih.gov/pubmed/17296539?ordinalpos=1&itool=EntrezSystem2.PEntrez. Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.P ubmed_Discovery_RA&linkpos=4&log$=relatedreviews&l ogdbfrom=pubmed
Quote:
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As monotherapy, rasagiline is well tolerated with an adverse-effect profile similar to that of placebo. As adjunctive therapy, it exhibits the expected adverse effects of dopamine excess, which can be ameliorated by reducing the L-dopa dosage. CYP1A2 inhibitors slow the elimination of rasagiline and mandate dosage reduction. Hepatic impairment has an analogous effect. The recommended dosage regimens for monotherapy and adjunctive therapy are 1 and 0.5 mg PO QD, respectively.CONCLUSIONS: Despite the well-documented selectivity of rasagiline, the manufacturer recommends virtually all of the dietary (vis-à-vis tyramine) and drug restrictions of the nonselective MAO inhibitors. Although useful, selective MAO-B inhibitors have a limited role in Parkinson's disease. Of greater interest is the potential neuroprotective effect of rasagiline and its major metabolite, 1(R)-aminoindan, which may have great utility in a wide variety of neurodegenerative disorders of aging. In addition, bifunctional molecules combining selective MAO-B inhibition (based on the active moiety of rasagiline) with acetylcholinesterase inhibition or iron chelation may eventually be useful in Alzheimer's disease.
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I suspect this drug can affect blood pressure, and its interactions with other drugs should be watched carefully.
Other drugs can raise blood pressure. Particularly the antidepressants in the SNRI family... Effexor, Cymbalta and Strattera. Also steroids. So taking Azilect with another drug with the side effect would be additive. Other drugs that can be additive for blood pressure include Ritalin and amphetamines (used to improve alertness). Some people react to high caffeine intake this way too.
Raising dopamine typically affects the cardiovascular system and raises blood pressure. This would vary from person to person.
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