Are you taking the name-brand or generic? It "might" make a difference. They may be using different binders -- the inactive ingredients that "hold" the medicine into the pill form.

Some MGers can only take the syrup form. You might ask if you can try.

Mestinon doesn't work for everyone -- BUT, you DO want to see if you CAN get it to work for you. Even with the somewhat bothersome side effects (that DO tend to subside with time), it is the LEAST damaging of the treatments, in my opinion.

Prednisone "might" help -- but, it can do some major damage to other body systems. It is the "good, bad" drug. Osteoporosis, diabetes, cataracts -- just to name a few of the likely side effects.

Cellcept, Immuran, Sandimmune -- other immune suppressants -- all carry the "possibilities" of cancer or organ damage or...........and there is no guarantee that they will even work!!

Plasmapheresis and IVIG carry their own risks........but, you may eventually need these anyway.

In short, Mestinon can be "uncomfortable" in the beginning -- HECK, it is a pain in the BUTT -- literally!!! You spend a LOT of time in the POTTY, at first!! But, if you can make a go of it, compared to the OTHER treatments, it really is not so bad.

Sorry to be so blunt, DeliaDee. The opinions expressed here are MY OWN -- and may or may not be the same as ALL other MGers. We are "snowflakes" -- different symptoms -- different reactions to meds -- and different approaches to the disorder we call "the beast".