Thread: new delivery of GDNF in the works
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Old 02-12-2010, 08:37 PM
paula_w paula_w is offline
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paula_w paula_w is offline
In Remembrance
 
Join Date: Aug 2006
Location: Florida
Posts: 3,904
15 yr Member
Default new delivery of GDNF in the works
From Linda H in pipeliner email:

Blood Brain Barrier
New blood brain barrier study findings have been reported from ArmaGen Technologies, Inc.
Feb. 12,2010

A new study, 'Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey,' is now available. "The brain drug development of glial-derived neurotrophic factor (GDNF) is prevented by the lack of transport of this protein across the blood-brain barrier (BBB). GDNF transport across the BBB can be made possible by re-engineering the neurotrophin as a fusion protein with a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR), which crosses the BBB on the endogenous insulin receptor," scientists in the United States report.

(that's ArmaGen not Amgen)

full article at:

http://www.newsrx.com/health-articles/1758909.html
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