Thread: Plant-based Parkingson’s drug Cogane enters clinical studies
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Old 02-12-2010, 11:40 PM
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Default Plant-based Parkingson’s drug Cogane enters clinical studies
Plant-based Parkingson’s drug Cogane enters clinical studies, says Phytopharm

Friday, February 12, 2010, 14:18 This news item was posted in Clinical Trials category and has 0 Comments so far.
http://www.dancewithshadows.com/pill...ys-phytopharm/

Phytopharm has also completed a Phase Ib stafety, tolerability and pharmacokinetic clinical study with Cogane, which was shown to be safe and generally well tolerated in both healthy volunteers and Parkinson’s disease patients over the twenty eight day study period.

When administered orally in several differenct preclinical models of Parkinson’s disease Cogane reverses the loss of dopaminergic neurones and elevates glial derived neurotrophic factor (GDNF)

GDNF has been shown to be particularly effective in re-growing damaged nerves. Since GDNF is a protein, it cannot be given orally (in tablet or liquid form) because it is degraded in the stomach and intestine, and also does not readily cross the blood-brain barrier.
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