1. Neuroreport. 1996 Sep 2;7(13):2171-5.

1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic
factor.

Naveilhan P, Neveu I, Wion D, Brachet P.

Institut National de la Santé et la Recherche Médicale, Centre Hospitalier
Universitaire, Angers, France.

Glial cell line-derived neurotrophic factor (GDNF) has significant therapeutic
potentials, in particular for neurodegenerative disorders. To determine factors
that would enhance GDNF expression, we analysed the effect of 1,25-(OH)2 D3 in C6
glioma cells. Treatment of C6 cells with 10(-7) M, 1,25-(OH)2 D3 for 48 h
elicited an 18.5-fold increase in the level of GDNF mRNA. In addition, our
results indicate that 1,25-(OH)2 D3 is effective at concentrations as low as
10(-10) M and that retinoic acid has additive effects. These data indicate that
1,25-(OH)2 D3 is a potent inducer of GDNF expression and suggest that 1,25-(OH)2
D3 may contribute to the regulation of GDNF in vivo.

PMID: 8930983 [PubMed - indexed for MEDLINE]


And more:


1: Sanchez B, Relova JL, Gallego R, Ben-Batalla I, Perez-Fernandez R.
1,25-Dihydroxyvitamin D3 administration to 6-hydroxydopamine-lesioned rats
increases glial cell line-derived neurotrophic factor and partially restores
tyrosine hydroxylase expression in substantia nigra and striatum. J Neurosci Res.
2009 Feb 15;87(3):723-32. PubMed PMID: 18816795.

2: Du F, Li R, Huang Y, Li X, Le W. Dopamine D3 receptor-preferring agonists
induce neurotrophic effects on mesencephalic dopamine neurons. Eur J Neurosci.
2005 Nov;22(10):2422-30. PubMed PMID: 16307585.

3: Lin AM, Chen KB, Chao PL. Antioxidative effect of vitamin D3 on zinc-induced
oxidative stress in CNS. Ann N Y Acad Sci. 2005 Aug;1053:319-29. PubMed PMID:
16179538.

4: Féron F, Burne TH, Brown J, Smith E, McGrath JJ, Mackay-Sim A, Eyles DW.
Developmental Vitamin D3 deficiency alters the adult rat brain. Brain Res Bull.
2005 Mar 15;65(2):141-8. PubMed PMID: 15763180.

5: Chen KB, Lin AM, Chiu TH. Systemic vitamin D3 attenuated oxidative injuries in
the locus coeruleus of rat brain. Ann N Y Acad Sci. 2003 May;993:313-24;
discussion 345-9. PubMed PMID: 12853323.

6: Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F. Vitamin D3 and brain
development. Neuroscience. 2003;118(3):641-53. PubMed PMID: 12710973.

7: Sanchez B, Lopez-Martin E, Segura C, Labandeira-Garcia JL, Perez-Fernandez R.
1,25-Dihydroxyvitamin D(3) increases striatal GDNF mRNA and protein expression in
adult rats. Brain Res Mol Brain Res. 2002 Dec;108(1-2):143-6. PubMed PMID:
12480187.

8: Koyama Y. [Functional alterations of astroglia on brain pathologies and their
intracellular mechanisms]. Nippon Yakurigaku Zasshi. 2002 Mar;119(3):135-43.
Review. Japanese. PubMed PMID: 11915515.

9: Wang JY, Wu JN, Cherng TL, Hoffer BJ, Chen HH, Borlongan CV, Wang Y. Vitamin
D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats. Brain Res. 2001
Jun 15;904(1):67-75. PubMed PMID: 11516412.

10: Rémy S, Naveilhan P, Brachet P, Neveu I. Differential regulation of GDNF,
neurturin, and their receptors in primary cultures of rat glial cells. J Neurosci
Res. 2001 May 1;64(3):242-51. PubMed PMID: 11319768.

11: Verity AN, Wyatt TL, Lee W, Hajos B, Baecker PA, Eglen RM, Johnson RM.
Differential regulation of glial cell line-derived neurotrophic factor (GDNF)
expression in human neuroblastoma and glioblastoma cell lines. J Neurosci Res.
1999 Jan 15;55(2):187-97. PubMed PMID: 9972821.