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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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However...
It may require high doses...
1. J Neurochem. 1985 Apr;44(4):1138-41.
Restricted transport of vitamin D and A derivatives through the rat blood-brain
barrier.
Pardridge WM, Sakiyama R, Coty WA.
The present studies measure the transport of retinol, retinoic acid,
1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], and 25-hydroxyvitamin D3 [25-(OH)D3]
through the rat brain capillary endothelial wall, i.e., the blood-brain barrier
(BBB). The vitamin A and D derivatives bind both to albumin and to specific
high-affinity binding proteins in plasma. In the presence of physiologic
concentrations of plasma proteins, the extraction by brain of all four compounds
was 5% or less.
PMID: 3838342 [PubMed - indexed for MEDLINE]
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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