Isis,

Godsend, YES! I'll second that. I went 12 hours yesterday tremor free! I am on day two with even less Propranolol and doing just as well (I took .5 to help control drowsinesss).

I have never had a tremendously long interval with Sinemet dosages. Before my pregnancy I could go to 4 hours, after delivery of my son, I dropped down to 2 - 3 hours. I believe that it is more beneficial to us to take a lower dosage of Sinemet more frequently (this is prevailing belief based on research and practice) as it really puts us in a state more akin to what we had going when healthy. I currently take:

three times daily

2 mg Requip
1 Sinemet 25/100 (supplemented every 2-3 hours to stay on)
1 Sinemet CR 25/100
5 or 10 mg of Propranolol (morning only) since yesterday

All this really does is keep me fluid. I do take 1/2 a Sinemet regular as needed to stay "on". This works well for me, but I do get dyskinesia when I overlap doses or take an extra bit of Sinemet if things wear off at work and I can't kick back on right away. I teach kids ages 5-11 and always have at least 25 pair of curious eyes looking at me.

I am trying to work on getting a morning dose of Requip at 3 mg into my system but can't handle the nausea. I have had that dosage work and it puts me back to baseline at the 4 hour mark with regular Sinemet.

I had a horrible experience with Azilect. First, I ended up with a rare side effect in younger onset people that results in severe joint pain. I looked and felt like an arthritic 80 yr. old when I woke up in the morning and found I had to take Ibuprofen every night because I ached. Stopped the Azilect and the pain disappeared. This drove me to the brink because at first I feared it was disease progression!

When I was on Azilect, I also took Mirapex and Sinemet. My doctor never advised me how to lower the levodopa, so I ended up with severe peaks and troughs in dopamine. When it peaked, I buzzed around the room, was manic, and delusional (in the sense that I was a little too happy). I crashed in between med dosages with tremor and mainly a numb painful tingling pins/needles feeling in my hands and feet also had disablind dizziness. The pins/needles stopped with the Azilect and the dizziness ended with the Mirapex.

What dosage of Propranolol is V taking? Does he feel it helps his tremor at all? Tell him to hang in there! I was maxed out on Sinemet and my doctor was pushing brain surgery just two months ago. If I can get a med regime together that works, there has to be something for all of us. Just keep trying

Imad, glad I'm not a guy for that very reason!! Mainly, the Propranolol makes me drowsy, so I am going to see if I can get by with just 5 mg. I hope you find something that works for you and soon!

Laura