When I first started I pre medicated with an advil and a tylenol and then took an advil and a tylenol every 4 hours. I don't need to any more. Now I take one advil and one tylenol when I take my shot. Then I take another tylenol if I start to feel cruddy. I take my shot in the evening because sometimes it makes me tired.

I like the tylenol arthritis, it seems to help the aches and pains better.