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Old 02-27-2010, 11:35 PM
jccgf jccgf is offline
Senior Member (jccglutenfree)
 
Join Date: Aug 2006
Location: Wisconsin
Posts: 1,581
15 yr Member
jccgf jccgf is offline
Senior Member (jccglutenfree)
 
Join Date: Aug 2006
Location: Wisconsin
Posts: 1,581
15 yr Member
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Anti-tTG antibodies are those associated with villous atrophy aka celiac disease.

The deamidated gliadin antibodies are new ... perhaps out for a year now. They are also more specific to villous atrophy than the original antigliadin antibodies were. This is ok if you are only concerned about villous atrophy.

What we know (and there really is a lot of evidence out there) is that many people have gluten sensitivity causing both gut and non-gut symptoms without having celiac disease. This is best determined by either the original antigliadin antibody (AGA IgA and IgG) or the stool test by Enterolab or a positive response to the diet.

I have tons of reading I could offer you... here are a couple articles:
http://findarticles.com/p/articles/m...c/ai_94538644/

https://www.enterolab.com/StaticPage...yDiagnosis.htm

and many other sources that discuss the difference between gluten sensitivity and celiac disease.
http://jccglutenfree.googlepages.com...sceliacdisease

I'm not sure what your symptoms are, but especially for those of us with neurological symptoms... gluten sensitivity can manifest with or without villous atrophy (villous atrophy required for a celiac diagnosis).

Your blood work and genetic testing does pretty much rule out villous atrophy aka celiac disease. It does not rule out gluten sensitivity, which can cause all the same things, and is associated with autoimmune disease and other wide ranging conditions. Check out The Gluten Fileif you haven't and just scan through it for areas of interest.

Hope this helps. I would absolutely encourage you to make the dietary changes and give it at least six months before deciding whether it is helped you. Many people know within the first weeks they are improving, but for others the improvement is slow, and better realized after many months. Log the symptoms you have now, with some scale for severity... and re-assess over time (month by month) for signs of improvement.

Cara
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