Mestinon was the first drug I was ever on for PN. It was before I had my skin biopsy. It didn't do much but make me kinda sick and weird feeling....then again, every one is different. After I got my skin biopsy back, they put me on IVIG....(which I had my first reaction to this time--I'm fine, but I had some odd things.)

Anyway, one can always try the Mestinon...