Hi I have been on LDN for months. When I first came down with the frozen shoulder that started this I was put onit. I started very low. Compounded by McGuff pharmacy in California. It needs to be done by one of the pharmacies listed on the lowdosenaltrexone.org site. I have mine done in a liquid to titrate. It took 50% of my pain away over night and that is when I was systemic pain. All I can say is it has helps calm this. The Lyme disease community and autism/fibro/MS people all use it .