I take buspar and trazodone at the same time....it just makes you sleepy so do it at night or if you take it during the day make sure you are okay to drive before going out and doing errands. My husband was on Atarax to stave off allergic reactions for a kidney stone surgery. It is a med that is used for anxiety to allergic reactions. Its another one that makes you drowsy so if you take them all at once, take them at night during a "safe" time when you know you aren't driving anywhere until you know how you react to them.