Oh yes, cramps here too. MS, I think so, but I'm not a Dr nor have I addressed it with one. I had not put it together till I saw Riverwind's post, but I also think socks help. I was having terrible cramps a few months back, then I started sleeping in socks (just because I was cold) and they went away. I'm still in socks and with no cramps. I think I'll keep sleeping in socks when summer comes. Better safe then sorry. Good Luck