poochie have you tried Magnesium tablets? Many people with MS are low in Magnesium. It helps with leg pain, cramps and constipation too. I take a lot but I am used to it. Try a 250 mg tablet. A few (3) keeps me normal bowel wise, pain wise, more (4 to 6) and it is the same as Milk of Magnesia, the laxative.

I take LDN too. That has helped with many types of pain and it is a mood lifter. I gave up on Lyrica, Neurontin and any other pain medication.

I have burning pain in my tops of my feet and legs. Nothing works for that for me. The LDN makes it tolerable, so I just deal with it.

Medication can cause problems you haven't had before, so be weary. They also can conflict with foods, herbs, and OTC meds too. I hope your pain gets better.

I don't believe pain means you are progressing. JMO