Is it possible that she should have slowly migrated to the three (3) doses of both medications per day, as opposed to jumping right into the three (3) does of both medications per day?

My guess is either she has gone too fast onto the greater dose, which could possibly mean she is overmedicated, or perhaps overwhelmed by the sudden increase in dosage, OR, that if the actual medication is different, which is not clear from your post, as in it is branded differently, or a change from generic to branded or vice versa, then this could change things, due to differences in the way tablets are formulated, making dopa more or less available. She could also, with increase in meds, be experiencing excessive sleepiness which might make her sound different. If possible ask for advice on this from her neuro, balancing meds is always a trial and error thing, and a sudden doubling of daily dose may just be more dopa than she needs.

Good luck with helping you mother sort this out, it seems she is responsive to meds and over time you may see more improvement.

Lindy

Lindy