View Single Post
Old 03-19-2010, 05:42 PM
reverett123's Avatar
reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
Default

Ron-
First, let me clarify that I wa well medicated but the meds were ineffective. Felt like a storm about to break but just would not, hour after hour. My muscles felt like a heart needing a defibrillator- weak, incoherent signals. But when that cold water hit, it was like a drill instructer yelled "ATTENTION!" and set off a cascade of some kind. Full on in ten minutes. Stayed that way for four hours and went to bed still on.

Somewhere along the line I read that a cold water plunge triggered a release of noradrenaline. Maybe there is a clue there.

In any case, I repeated the experience this morning with similar results. Tried it again this afternoon at the first signs of going off and got little effect.

Quote:
Originally Posted by Ronhutton View Post
Hi Rick,
I have mentioned previously that I occasionally switch on when I have had no meds, such as when I get up, or in the evening when my meds have long worn off. It happens 3 or 4 times a month, and I don't need the cold shower!!!. However it only lasts up to an hour maximum, sometimes only 10 minutes.
You say it took about 10 minutes to switch on after you got out the shower, but how long did it last? Have you ever had my type of "on" when you are unmedicated, and without the shower.
Just one thought, Ice cold water on the head has an effect on the permeability of the BBB. I can find reports which say the BBB decreases in permeability, and others which say it increases. If it decreases it, you would probabl;y switch on, and off again when it warms up and you have your defective BBB back?
Best wishes
Ron
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
reverett123 is offline   Reply With QuoteReply With Quote