I've been on LDN for about 5 years, 3 mg. It has helped me, I don't have attacks anymore, it does not keep it from progressing, but it has slowed it down for me. Tell your doc you have nothing to loose, the dose is so small, there is no side effects and you might as well try it. I took avonex for a while, the side effects were so bad for me I stopped it, and started having attack after attack, then went on LDN and they stopped, it will take a while for it to work for you, it isn't for everyone, I have a friend that has PPMS and it didn't help her. You just have to try it. Everyone to their own. Good luck, let us know.