I have had no relapses in the 7 yrs on LDN and have not progressed in disability.......except for the short flares caused by illness=a cold or infection=a UTI and I have progressed to 70 yrs young=lack of strength.

My MS symptoms lessened in the first 2 years and have remained the same. I felt better and healthier in the first year and still do to this day.

My DD is also on LDN for the last 5 yrs and has had one relapse, when she stopped taking LDN for a week. She is back on it and back in remission.

My only regret is, not having LDN when I was RRMS. I was SPMS when I started and have some permanent nerve damage and symtoms that are here to stay.

LDN usually works better on RRMS peeps, as, if you can halt or shorten the exacerbations, you can halt or slow the progression.

There have been limited studies, but have been too short and not enough people, to prove a lot. There is no money in big pharma doing a big study, on an approved drug.

Good luck to all who are giving it a try....and Good luck on educating your Neuros, so they will prescribe it for you.