Yes, it does.
And also, dicolfenac which is one NSAID has recently been shown to cause liver damage when used topically!
http://www.fda.gov/Safety/MedWatch/S.../ucm193047.htm
The concentrations in a cream are not usually very high.
Gabapentin is not metabolized by the liver anyway. So first pass is not an issue.
The whole idea is to reduce the doses, reducing side effects.
Some people really like these formulations, and others not.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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