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Old 03-24-2010, 11:05 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

Only Celebrex is left of the Cox-2 specific NSAIDs...and it is not 100% specific.

All the rest suppress Cox-2 and Cox-1. It is the Cox 1 that gets to the GI bleeds. The Cox-2 when suppressed too much gets to the heart attacks (because suppression of prostacyclin--a Cox 2 that dilates blood vessels is blocked).

Voltaren may just be more liver toxic than the others. It was in the past just a me-too drug put out by Searle to compete with Naprosyn and Ibuprofen. Because it is lipophilic it is used topically to cross the fatty skin layer better.
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