Annie,

I really appreciate your taking all the trouble to explain this.

I couldn't remember where I heard about the half-life of Mestinon being three to four hours, but that's what I find when I type "Mestinon half-life" into Google. For example:

http://www.medsafe.govt.nz/Profs/dat...estinontab.htm
http://www.flexyx.com/M/Mestinon.html
http://emc.medicines.org.uk/medicine...+60mg+Tablets/ (see 5.2)

However, I do understand that the there are so many variables here that speaking of the drug's half-life might be worse than useless. Thanks for that. I had been worried that taking the drug every three hours, as I've been doing, might make it pile up in my system. That seems unlikely to me now, since I get weak at about 2 1/2 horus after each dose. So your explanation is very helpful to me.

Thank you for the invitation to ask questions! I have some more. Tell me if this sounds reasonable: it seems to me that the Mestinon takes care of two problems for me very well: my double vision, which hasn't bothered me at all since I started the drug; and the side muscles of my neck. My head flops from side to side only when it's almost time for my next dose. However, it doesn't seem to strengthen the back muscles of my neck at all--seems like that gives me trouble without regard to when I've taken the drug. Also, the drug seems to help me not to tilt when I walk or stand, but only somewhat--on a bad day, it doesn't seem to help at all.

Is that possible, or am I definitely imagining things?

Thanks for what you said about the heat and cold. I wonder if my sense that I am better on sunny days is really a matter of warm, not sunny. Our house isn't well heated in the winter (wood stove, big house). I will also remember what you said about the heat, because it's amazing how long it sometimes takes me to put two and two together!

Thanks again, Annie, for taking the trouble to share all this knowledge with us. You're helping me a lot.

Abby