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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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Ron, something just occurred to me.
In rereading my post above, I suddenly focussed on
<Then there is the matter of the fact that the first damage (or at least Lewy bodies) show up in the nose (olfactory bulb) and stomach wall. Since LPS is the main component of house dust, that could explain the nose and maybe the stomach too.>
in the context of our old discussions about the nose as a way to bypass the BBB. If the LPS content of house dust is a factor, then we have the possibity of a steady seapage along the axons from the olfactory bulb into the brain itself.
The obvious question of why, then, doesn't everyone get PD could be explained by the fact that people exposed to LPS prenatally have an alterred sensitivity to adult exposure (pretty well established).
And, again, curcumin comes to the rescue because it is one of the few things that counter the effects of LPS, thus explaining the Indian paradox.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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