Let's just put it all on a table and look at it. I am fairly sure that we have all said it already. First we have LPS-induced inflammation (quantitative and qualitative according to amount and duration of exposure) causing a corresponding leakage of the Blood Brain Barrier (again quantitative and qualitative according to duration and severity of inflammation), which, in turn, allows entry of any number of neurotoxins into the brain to interfere with processes determined by the toxins size, shape and mode of action.

In this scenrio we have

initiation ( An act that sets in motion some course of events)

potentiation (medicine) the synergistic effect of two drugs given simultaneously)

and

facilitation (neurophysiology) phenomenon that occurs when two or more neural impulses that alone are not enough to trigger a response in a neuron combine to trigger an action potential)
(definitions provided by Easy Office Dictionary)
of not one but any number of neurodegenerative diseases, a majority of which should be preventable by eliminating the innitial cause of the inflammation.

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mchael b.