Hi Rick,
There does seem to be a connection between hypertension and PD.
There is a lot of data now on the beneficial effects on PD of anti hypertension drugs, like isradipine. It stands to reason that a high blood pressure will force a path through the BBB, more than a lower pressure.
I believe that PWP's have a continuous higher BBB permeabilty than a healthy person. Things like a stressful situation can cause a temporary further widening of the BBB, and we freeze. Possibly events like trying to lift a very heavy weight may have a similar effect. Could this cause a spike in blood pressure?
The report says,
" Intermittent openings
of the barrier observed in chronic hypertension may lead to accumulation of
extravasated serum proteins"
So is this how we get accumulated alpha-synuclein?
Ron