Ron- I can report firsthand that there is an acute rise in my BP when I am off and even more so when I struggle to physically overcome it.

It should not be surprising, since BP is increased when the muscle tone in the walls of the arteries increases, as I presume it would when all the other muscles are clenched. I suspect that a different set of rules apply for veins.

So, if this picture is true, then at some point PD would become self-perpetuating and progression accelerate as the rigor of the muscles indirectly compromised the BBB. <How'd I do, Boss? >

PS- Just found that dyskinesia correlates with a drop to near normal BP.