Definitely do not freak out It never helps.

I've wondered about that as well. I have had constant pain in my hands for over a year. Steroids don't touch it, but Lyrica helps. What does it mean when a sx doesn't go away? Does it mean I am advancing to SPMS? And what does that mean?

I thought it would be bad news to be "upgraded" to SPMS, but it seems it doesn't really change anything. You still go through the same meds, continuous sx. It just means some symptoms don't go away. I have sx that never seem to resolve.

I'd be interested to know if anything changed for anyone when their dx changed from RRMS to SPMS.