LOVE IVSM! I wish I could have it all the time, I'm not joking. It does keep me up late a little and make me irritable (I'm told) but they seriously help me every time.
My system has always been robustly tolerant of such things, I'll admit it, but please don't assume they're not for you until you've given them a chance for yourself.
Prednisone does a number on my mood and makes me eat everything in sight, nonstop, morning, noon and night.
They're delicious with fava beans and a nice chianti.