Wanted to include this private message response from Ron when I asked him if he had any evidence to the contrary about his BBB theroy.[with his permission]. it has a little more information.

Ron said:
Really, I have not found a single thing which argues against this theory. Every chemical which is beneficial to Parkies, also closes the pores of the BBB.
curcumin, GDNF, folic acid, biberry extract, etc.
Every chemical or treatment which opens the pores, causes an intensification of symptoms, stress, old age, nitric oxide, carbon monoxide, organic phosphates,
High blood pressure will weaken the BBB, and it is
associated with a high incidence of PD.
PD people have been shown to have abnormally high levels of iron in their blood
In http://www.medicinenet.com/script/ma...ticlekey=62531
where it is shown that if a baby has an underdeveloped BBB, it can absorb high levels of iron, leading to PD in adulthood. If we have a
leaky BBB since birth, it would account for the high levels of iron,
I guess there must be arguments against the idea, but i have not found any yet.

Paula