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ex-Member
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Join Date: Sep 2006
Posts: 110
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ex-Member
Join Date: Sep 2006
Posts: 110
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Quote:
Originally Posted by paula_w
if a baby has an underdeveloped BBB, it can absorb high levels of iron, leading to PD in adulthood. If we have a
leaky BBB since birth, it would account for the high levels of iron,
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People with Hereditary Hemochromatosis genetically accumulate iron, at levels way beyond any of those found in people with Parkinson's Disease. If iron accumulation caused Parkinson's Disease, then everyone that had Hereditary Hemochromatosis would also have Parkinson's Disease. Yet in a study carried out in Ireland, where HH is at it's worst, none of the people with Hereditary Hemochromatosis had Parkinson's Disease. How do you explain this worst case scenario of iron accumulation not resulting in any cases of Parkinson's Disease at all.
If the blood brain barrier deteriorates with age, and thereby makes Parkinson's Disease more likely, how do you explain the three year olds found to have Parkinson's Disease, and the fact that amongst the very oldest of people - those between 110 and 120 years old, Parkinson's Disease is virtually unknown. At their age, if the theory was right, it should be almost inevitable that they get it, but virtually none of them do.
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