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Old 04-02-2010, 04:45 PM
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jackD jackD is offline
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Join Date: Jan 2008
Location: Maryland outside WASH DC
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jackD jackD is offline
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Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
15 yr Member
Default MS is a TWO (2) stage disease

MS is a two stage disease

1st is the INFLAMMATORY PHASE.

2nd is the DEGENERATIVE PHASE

I have read from several sources that it takes about 10 years to go from PHASE 1 to PHASE 2. This might be modifed(extended or cancelled) greatly by taking a Disease Modifying Medication.

The BAD actors that are targets for reduction in PHASE 1 are seen in the below figure are Gamma Interferon, TNF-a, IL-12,IL-6 and MMP-9s.

In PHASE 2 the target for reduction is "EXCESS GLUTAMATE".
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Multiple sclerosis: a two-stage disease by LAWRENCE STEINMAN
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http://home.ix.netcom.com/~jdalton/ms-two-stages.pdf


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Last edited by jackD; 04-02-2010 at 11:51 PM.
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