MS is a two stage disease
1st is the INFLAMMATORY PHASE.
2nd is the DEGENERATIVE PHASE
I have read from several sources that it takes about 10 years to go from PHASE 1 to PHASE 2. This might be modifed(extended or cancelled) greatly by taking a Disease Modifying Medication.
The BAD actors that are targets for reduction in PHASE 1 are seen in the below figure are Gamma Interferon, TNF-a, IL-12,IL-6 and MMP-9s.
In PHASE 2 the target for reduction is "EXCESS GLUTAMATE".
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Multiple sclerosis: a two-stage disease by LAWRENCE STEINMAN
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http://home.ix.netcom.com/~jdalton/ms-two-stages.pdf
jackD