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The Vagus Nerve (pictured above) is involved in absolutely every one of these problems. So could it be that the Vagus Nerve suffers inflammation which causes a leaky seal at the BBB and allows any number of substances to not only penetrate th;e BBB but penetrate it at the point at which neurotoxins would have to go in order to affect Parkinson's disease. I will be editing this in a few minutes to include some documentation.<End Quote>

There is a German scientist named Braak that within the last ten years has been pointing some very interesting things involving, among other things, the vagus nerve. There are little knots of protein found in the neurons of PWP and they are called Lewy bodies after the guy who found them. All that is really known about them is that they are always found in the substantia nigra of deceased PWP. In fact, they are the "gold standard" for defining PD.

What Braak noticed was that the Lewy bodies (LB) actually showed up in other areas of the nervous system *years* before they made it to the SN. In fact the first places they show up are the olfactory bulb of the nose and an area in the stomach wall. Then they spread, step by step and from two directions, into the brain and eventually show up in the SN and our problems begin.

Our bodies actually have a transport system along our nervefibers and it goes in both directions. The route taken from the nose is along the fibers that conduct the sense of smell. The route from the lower regions is, you guessed it, the vagus nerve.

So here we have another possible hole in the BBB defences. And something moves along the fibers that pass through that hole leaving a trail of LBs behind. Toxin? Virus? Pesticide?

My own bet is the toxins like those put out by our old friend H pylori. But there is no reason to assume that is is just one or the other. Maybe that is part of why we vary so much is speed of progression.