I have had PD for over 10 years and I take mirapex and sinemet daily and these meds work fairly well in handling my symptoms . But over the last week I came down with some sort of stomach virus and fever which have persisted for 5 days. Each day I have noticed and been troubled by the fact that the first couple of doses of my mirapex and sinemet have not worked at all. My symptoms have not been under control and its not till I'm halfway thru my 3rd dose (about 5 to 6 hours into my day) that I start getting any relief. I 've never had this happen to me before? Has anybody else had this problem? What do you think is the cause? Is there anything I can do during this sickness to get my meds to absorb properly? Your help is much appreciated.