I'm on 2 25/100 Sinemet 4 times a day and sometimes I sneak one at the end of the day. It works well in the morning time, no so much later in the day. The doctor originally had me taking it every four hours but I find every 3 hours keeps me from fluctuating on and off as much. I talked to two MDS about my limited response to sinemet which they expected to be much better because I'm young. I asked if I should take more, but they said I'm already on a substantial dosage. is 6 x 25/100 per day a lot?

Robert