Hi robert,

I thought i was running out of options, taking 1 1/2 to 2 25/100s every two hours. adding nortriptyline reduced rigidity and shortens dystonia, Then I tried stalevo and it is helping pretty much to the point of my gradual reduction of sinemet.I can see and feel quite a difference. It takes out the grindy feeling from too much activity within.

These changes with increases and dosages still adjusting have allowed me to see what a destructive path I was on chemically.

So here's hoping it does not cause prostate cancer or any other kind. i found that i cannot take it past 4 or so pm - otherwise i wake up immediately alert and with a knot of anxiety in my stomach the next morning.

So i was probably topping out at 1600 mg of sinemet,with amantadine and sleep aide, then hit some crazy things that i know are sinemet related but then why doesn't everyone do this and that? well how do we know what anyone does on that much sinemet? but i digress.......

turns out there were options and i learned a lot. I don't know what all you've tried, but some of us seem to agree on the sinemet/comtan combo with or without amantadine for dyskinesia and possibly an anticholinergic or muscle relaxant. Sleep aides and what ever other conditions you might treat, i have hypothyroidism and acid reflux , but reflux has cleared up a lot either due to nortriptyline, which reduces muscle cramping and dystonia or stalevo.

ok that's a medication update - i hope others post theirs - then we could make some comparisons geographically, in treatment approaches.Also compare doctors to specialists.

Important to add that with stalevo and fewer 25/100 my curled hands have opened and gained back some mouth movement and shape.

and answer robert's question.

over and out