Way cool, Nicky! Super find.

Yeah, so, it looks like an autoimmune process interferes with the ability of the AChE (the enzyme) to "mop up" after acetylcholine, causing too much of acetylcholine. Kind of the opposite of MG.

So MG is to, for example, the Rapsyn CMS mutation where you don't have enough acetylcholine as this new antibody is to Slow Channel Syndrome CMS where there is too much.

I am guessing this article is from Italy or somewhere like that? I haven't been able to find an actual test here except for what has been done in clinical studies on animals. Have you found one?

Well, this just emphasizes what people like Angela Vincent have said. MG AChR and MuSK antibodies are only the tip of the autoimmune iceberg.

Very fascinating indeed. MG may be "the most well-understood autoimmune disease" (which I don't agree with) but the neuromuscular junction is infinitely perplexing.

Annie

http://www.springerlink.com/content/kvhn34021pq76124/

http://www.abcam.com/Acetylcholinest...y-ab35384.html

http://www.williams.edu/imput/synapse/pages/IVA2.html

Susan, This reminds me of how you said you feel better in the sun/heat. Heat increases the enzyme. Hmmmm . . .