I started R-lipoic acid, along with several other supplements, in Oct. '09, so it's difficult to tell "What's doing what". My neuropathy (idiopathic/?re. to Paxil withdrawal) seems to have been relatively stable since then. My symptoms, which are predominately numbness/tingling/shooting sensations, do, however, tend to wax and wane. During the last few days, the discomfort in my feet has increased, so I'm thinking of increasing the dose of R-lipoic from 100mg to 300mg daily. Any one have experience with lower vs. higher doses? Mrs. D, what are your thoughts? If I were to increase the dose, would it be better to take it as one dose or in 3 divided doses? Sorry to sought of "hijack" the thread....Thanks.