I agree with Nicky. I was on 60 mg of Prednisone for 4 months then they tappered me down to 15 mg. My double vision came back like new so they increased it to 20mg. where I am now. I never had trouble with my legs at all (except with fibromyalgia) and now complain of my legs feeling like elephant legs and sort of atropied. The side effects I have had from Prednisone have been: lack of sleep, weight and fluid gain, bruising across my back and rashes, wheezing and labored breathing - just pant talking on the phone. I lost about 1/3 of my hair while on high doses. It now has come back and has come back curly. Never had curls! Strange! I have had skin problems where I never had them before - my face has broken out, I have dry rough places on my chest, arms and back - never had before! I got thrush while on high doses. I can't even begin to remember allt he side effects. AND - the double vision came back! I am now on 20 mg daily of Pred and 2000 daily of CellCept. I put myself back on Mestinon two weeks ago just to see what would happen with my left eye twitching allthe time (did no good to start with last year). Believe it or not, it has helped. It has been inconsistent, but has helped. I have found that working under certain lighting at the office and being on the computer more makes my eye twitch more. It is very discouraging. If I knew now then what I know now, I would never have started on Pred. I go back to MUSC this Thursday for another SFEMG to check the status of the MG and also in the arm and neck to see if it has started spreading to the body because of the breathing and the way my legs feel. Enough about me. I agree with Nick - I would be very leary about starting on Perd. Good luck. Kathie Glenn