Hi I could be wrong but I don't think Mayo or Cleveland Clinic does ketamine. If that is what he would like to try in terms of treatment I would call to see. For ketamine Dr Shwartzman or Dr Kirpatrick and there are a few others the names of which I can't recall but have been mentioned here. As for it being the last thing to try I disagree there is more options so try to hold to hope. I think a starting point is to call the places you have been suggested and explain the situation and what you are looking for. You can even ask if they do ketamine. You sound like a very caring girl friend and I hope your boy friend gets to a better place soon