a poster here Brian who has been able to a large degree to reverse his PN caused by pre diabetes with tight sugar control and his pain with the use of magnets, has posted that at times he had to titrate down his medication for a period of time and then titrate back up, working with his doctor, because he would become too tolerant of high doses and titrating down and back up again allowed him to keep using the same medication. It would regain its effect that way. If you do a search of his name you might find the posts.