My calves have always hurt also - I am 44 and like you have not found the cause and am desparate to find this - ever hopeful that there will be a cure. This forum helps me so much when I am low, I asked my doctor for lidoderm patches tonight and so far so good, I will keep you posted but my pain has went from 7/8 today to 1/2 tonight - i cannot remember this amount of pain relief for a long time.