Yes my calves ache and sometimes they are so tight it feels hard to propel if that makes any sense. I asked my pain doctor and neurologist and he said it was all part of my peripheral neuropathy and what can manage the pain for it will also help with the calves. Now I am not sure if this is correct but what I was told. I was trying zanaflex and also klonopin. For me I don't know how much either work when I am in a flare. I'm also on neurontin and cymbalta.I also don't know the cause of mine which was dx at 28 and have been for so many diagnostic tests basically there is no more at the moment and I am on to pain treatment. 30 is a very low dose of cymbalta for pain control it is often 120 and that is what I am on. I am sorry I wish I had more to offer.