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Old 04-30-2010, 02:13 PM
imark3000 imark3000 is offline
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Join Date: Nov 2007
Location: Calgary-Canada
Posts: 821
15 yr Member
imark3000 imark3000 is offline
Member
 
Join Date: Nov 2007
Location: Calgary-Canada
Posts: 821
15 yr Member
Default i think this is current article

every body: following article confirms your input. Inspired by Ron's postings, I have been taking 900 mg curcumine + bioperin for few years and because it is cheap I am tempted to double the dose .. how ever I did not .. following an arabic saying " Too much of a good thing will turn it into a bad thing "
but seriously: dose is a real issue
Imad

Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's Disease cell model

Overexpression and abnormal accumulation of aggregated alpha-synuclein (alphaS) have been linked to Parkinson's disease (PD) and other synucleinopathies. AlphaS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species.

Both genetic mutations and chronic exposure to neurotoxins increase alphaS aggregation and intracellular reactive oxygen species (ROS), leading to mitochondrial dysfunction and oxidative damage in PD cell models.

Results: Here we show that curcumin can alleviate alphaS-induced toxicity, reduce ROS levels and protect cells against apoptosis. We also show that both intracellular overexpression of alphaS and extracellular addition of oligomeric alphaS similarly increase ROS which induces apoptosis, suggesting that aggregated alphaS may induce similar toxic effects whether it is generated intra- or extracellulary.

Conclusions: Since curcumin is a natural food pigment that can cross the blood brain barrier and has widespread medicinal uses, it has potential therapeutic value for treating PD and other neurodegenerative disorders.

Author: Min WangShanta BoddapatiSharareh EmadiMichael Sierks
Credits/Source: BMC Neuroscience 2010, 11:57

Last edited by imark3000; 04-30-2010 at 03:14 PM.
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