Wow, that's amazing--25 doses a day! I think most people in your situation would take three pills every three hours instead, but it actually makes more sense to me your way, since the pills have such a short half-life.

I did experiment with taking more--actually (my neuro's suggestion), taking the same dose, but closer together. I found that unless I'm having an especially busy day, any closer than 3 hours apart and I start twitching all over. That makes sense to me. If it's acetylcholine that stimulates the muscles, then too much acetylcholine and your muscles start moving on their own: twitching. So I believe I've found my personal limit.

My experiment yesterday leads me to believe that the Mestinon is definitely helping me. I had a bad day without it. But, like a lot of people here, I find that Mestinon can only do so much. I do expect to try an immunosuppressant eventually.

Abby