Good post Michael...........Mine all started with my neck. I went to my GP (primary physician) told him I was feeling all disoriented and weird. I asked him if there was anyway my neck DDD (degenerative disc disease) could be slowing the flow of blood to my brain. He replied saying no, that the brain has no blood in it. He said I probably had the flu. And gave me antibiotic to take for 5 days. I knew that that I didn't have the flu. From that incident, was the beginning of some serious change in me? The neck problem I think was the beginning of my problems and I feel it had something to do with bringing on my PD so fast. My cervical DDD of the neck/head area has been just as much of a problem for me as the shaking of having PD. Maybe this is the breach in the blood brain barrier you mention. Anyway I think you’re on to something.