Actually, it is simple only in retrospect.
In the case of both immune and endocrine involvement, cytokines and hormones serve their respective systems as messengers. They are also neuroactive - they act as neurotransmitters and affect our normal abilities. This is in addition to the damage to the SN. The latter is a chronic situation while the former is an acute.

About two years ago, Ron Hutton gave us a demonstration of this when an infected tooth made him near helpless for two weeks. His immune system's cytokines laid him low.

I myself have just performed a similar demonstration of the ability of the endocrine system to do the same thing via hormones in response to extreme stress.

In both cases it was the body's reaction that did the deed, not the outside force.

If an antibiotic has an antiinflammatory effect, it can block further production of the cytokines. Anecdotal reports of such action exist for amoxicillin and penicillin VK. Minocycline has also been used.

Given how absurdly simple it would be to determine if it warranted further study, what possible reason could justify not doing so?