The role of the neurotransmitter acetylcholine may ultimately suggest new Parkinson's disease treatments. While a key Parkinson's symptom is tremor, an advanced stage symptom is the inability to start a movement, such as walking. Symptoms associated with Parkinson's can be helped by reducing acetylcholine-mediated neurotransmission in the brain, but little work has focused on brainstem muscarine receptors in this disease.

I tried to talk about exactly this at my last appointment and was flatly told that anticholinergic medication is 'very old fashioned and out of date' . I have read that such medications were a mainstay of PD treatment prior to l-dopa, and there must have been good reasons for that. I took such three drugs for different reason than PD, over nearly 4 years, they are regularly prescribed for other conditions, and discontinued them due to side effects, and my query was because I had lost fluidity of movement since stopping them.

The consultant who prescribed them was aware that they enhanced mobility in PD.

And then this crops up!

Paula, I know you have been looking at this for ages.....

Thank you so much for this post, Imad.

Lindy