Senior Member
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Join Date: Sep 2006
Posts: 1,271
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Senior Member
Join Date: Sep 2006
Posts: 1,271
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Thanks for this post......
The role of the neurotransmitter acetylcholine may ultimately suggest new Parkinson's disease treatments. While a key Parkinson's symptom is tremor, an advanced stage symptom is the inability to start a movement, such as walking. Symptoms associated with Parkinson's can be helped by reducing acetylcholine-mediated neurotransmission in the brain, but little work has focused on brainstem muscarine receptors in this disease.
I tried to talk about exactly this at my last appointment and was flatly told that anticholinergic medication is 'very old fashioned and out of date' . I have read that such medications were a mainstay of PD treatment prior to l-dopa, and there must have been good reasons for that. I took such three drugs for different reason than PD, over nearly 4 years, they are regularly prescribed for other conditions, and discontinued them due to side effects, and my query was because I had lost fluidity of movement since stopping them.
The consultant who prescribed them was aware that they enhanced mobility in PD.
And then this crops up!
Paula, I know you have been looking at this for ages.....
Thank you so much for this post, Imad.
Lindy
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