What Sally said is exactly how it works. It is not to keep you up, like a anti-fatigue medication. And it does not make endorphins at will.

Only when our body starts making endorphins on it's own, at night, it blocks them, then the body thinks it needs more, so when the blocking ends, we have many increased endorphins. At that time, most feel it starts helping with pain because of the endorphin rush and energy by morning.

It is not an upper pill, or energy booster to take during the day. Read the LDN website again Eddie, it might help. I re-read it often. I have a lot to learn myself.