Should an early-stage PD patient try to keep dopamine agonist (e.g. RequipXL) use to the minimum (put up with as much symptom as reasonably tolerable) so as to extend useful life of this med before starting levodopa? Have read and been told by neurologists a clear YES (“...the use of any dopamine agonist will eventually cause a decrease in the sensitivity of the same dopamine receptors that it is intended to stimulate”) as well as a clear NO (“...it’s the progression of the disease that makes the drug less useful, not anything the drug itself does”). Can you help me find the answer, backed up by credible research? Would be grateful for the citings/articles. Thanks much!