Erin, I take Ritalin. I guess street name would be an 'upper'!!!! It helps some but I still have days that my DH just knows not to expect anything from me. The fatigue was what got me my disability. The person there that gives info to the judge, can't remember what his title is, told the judge that I would be calling in sick at an average of 2 days every 6 weeks. Fatigue gives no warning, the type of nights sleep you have the night before makes no difference. One thing that has helped me though was a sleep study which showed I have sleep apnea. I wear a CPAP and it really does affect my sleep and rest.